The Technological Hierarchy for the Removal of Undesirables and the Subjugation of Humanity (THRUSH) launches an attack on the New York headquarters of the United Network Command for Law-Enforcement (UNCLE) in order to kill Alexander Waverly, head of the agency. But the THRUSH agents are caught when they try to enter the headquarters building, and rather than be apprehended, they do themselves in by consuming poison. The assassination attempt was made because Waverly has become aware of the plot by THRUSH murderer Andrew Vulcan to murder a visiting dignitary, Premier Ashumen of Natumba. To stop him, top UNCLE agents Napoleon Solo and Illya Kuryakin are sent to prevent any harm coming to the African leader.