Charming and single Joey Tribbiani (series star MATT LeBLANC) embarks on his own and moves from New York City to Hollywood, hoping to truly make it as an actor. Joey says good-bye to a time when his friends were his family and welcomes the chance to turn his family into his friends. After accidentally ending up in Dallas instead of taking a connecting flight to California, Joey finally arrives in Los Angeles and reunites with his high-strung older sister Gina (series star DREA de MATTEO), a strong and sexy hairdresser. While Gina shows Joey the apartment she arranged for him, her genius 20-year-old son, graduate student Michael (series star PAULO COSTANZO), who literally is a rocket scientist, arrives. Although Joey lacks book smarts, he more than compensates with his people skills, making him the best new friend his nephew could ask for. Joey finds out from his flamboyant agent, Bobbie (series star JENNIFER COOLIDGE), that the cop show he was starring in has been cancelled, forcing him to begin auditioning for roles again. When Michael asks to move in with Joey because it's difficult living with overprotective Gina, Joey is afraid to confront his sister--until he learns what a great cook Michael is. Gina is furious to find out that Michael wants to move out of her home, but Joey persuades her that her son needs to change his life, just like Joey did. She reluctantly allows Michael to move in with her brother.Meanwhile, Joey befriends his new neighbor, Alex Garrett (series star ANDREA ANDERS), a lawyer specializing in environmental law, but he soon learns that she's married.