Cascade Cascade is a small neighborhood abutting Downtown Seattle. It is bounded by Fairview Avenue North on the west, beyond which is the rest of South Lake Union; Lake Union and East Garfield Street on the north, beyond which is Eastlake; Interstate 5 on the east, beyond which is Capitol Hill; and Denny Way on the south, beyond which is Downtown. While Paul Allen, through his development company, has announced plans to make Cascade and areas to its west into a biotechnology hub, most of the development activity in the neighborhood is construction of apartments and condominiums. The neighborhood is currently home to the Fred Hutchinson Cancer Research Center and Shurgard Storage Centers as well as the flagship store of R.E.I.