Award-winning Chelsie Lately is the E! networks's late-night talk show that invites viewers to join hostess Chelsie Handler every weeknight for a half hour of comedy, interviews, and charming insights on the latest entertainment news. Handler is accompanied by co-host Chuy Bravo and narrator Mike Rock. Handler and Bravo are joined nightly by guest commentators and an interviewee.

Guests engage in quick-witted banter, offering refreshing insights on the latest happenings in pop culture and entertainment news. Viewers of Chelsie Lately are treated to sketch comedy, such as the long-running Fat Baby sketch.

The show was the winner of the 2009 Teen Choice Award in 2009, and has also been nominated for a People's Choice Award in 2010. More than 700 episodes have been filmed, for three seasons. The show has spawned two comedy specials and one spin-off reality TV show.