Grey's Anatomy is a medical drama created by Shonda Rhimes that premiered on ABC in 2005. Since its creation it has won several awards, including two Emmy's, and it has become one of the most watched primetime shows. Grey's has earned high ratings since its premier and has continued to draw large audiences.

Grey's Anatomy focuses on the lives of five surgical interns at the fictional Seattle Grace Hospital. The show follows these five and their mentors as they proceed through their internships, eventually becoming surgical residents. The drama in Grey's Anatomy is derived from a mixture of medical and personal concerns. The show's main characters frequently interact and intertwine against the already hectic backdrop of the hospital. Affairs and feuds between various characters are common throughout the show. As compared to shows like E.R. the focus of Grey's Anatomy is more heavily placed on personal rather than medical drama.

The title, Grey's Anatomy, is a reference to the famous medical textbook, Gray's Anatomy.