Edie Falco plays as title character Jackie Peyton in the Showtime original series, Nurse Jackie. Nurse Jackie a New York City nurse in a busy city hospital facing challenges from both her career and her life. Nurse Jackie straddles the line between comedy and drama, with light-hearted scenes to be found among the serious issues that the show explores. Jackie Petyon has been viewed as an unethical portrayal of a nurse, often using pain medications to deal with her stress.

Nurse Jackie has a cast of both regular and recurring characters. Eve Best plays Dr. Eleanor O'Hara, Jackie's best friend. Zoey Barkow is a new nurse in the hospital and is played by Meritt Wever. Peter Facinelli plays Dr. Cooper, a stoic character that is laced with anxiety. Eddie Walzer, played by Paul Schulze, is a pharmacist that Jackie is having an affair with. Other actors include Dominic Furmusa, Anna Deavere Smith, and Haaz Sleiman. Nurse Jackie has had several recurring characters throughout the shows first two seasons.

When it debuted, Nurse Jackie was the highest rated premier on the Showtime network and has been nominated for multiple Golden Globe, Screen Actors Guild, and Primetime Emmy awards. In 2010, Edie Falco won a Primetime Emmy award for Outstanding Lead Actress for her portrayal of Nurse Jackie. Currently, Nurse Jackie is shown in nearly 30 different countries.